Keep an eye on Intently (1)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a solid inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for feasible dosage changes.fluconazole will boost the level or impact of diazepam by affecting hepatic/